A NOVEL SYNTHESIS AND CHARACTERIZATION OF POLY[4-IMINO(N-4-ETHYLBENZOATE)BENZENE P-STYRENESULPHONATE] AND THE INVESTIGATION ON POLYMER ABILITY FOR DRUG RELEASE
Vol. 10, No. 1, 59–67
چکیده
The present paper describes the release of benzocaine from polymer carder. The chemically controlled release method has been applied in which the benzocaine (drug) with active group (NH2) links up with the spacer group (p-hydroxybenzaldehyde) by imine bond formation. The resulting schiff base reacts with the monomer p-styrenesulphonyl chloride. The obtained monomer is polymerized by AIBN as an initiator at the temperature range &0–70 ' C. The obtained polymer was identified by IR and NMR spectroscopies. Gel permeation chromatography (GPC) was used for determination of average molecular weight of drug pendant polymer. The hydrolysis of dog polymer conjugates was carried out in cellophane membrane dialysis bag containing aqueous buffer solution (pH 1.2) at 37 'C. Detection of hydrolysis solution by UV spectroscopy showed that the drug can be released by hydrolysis of imine bond between the drug and spacer group. Key Words: controlled drug release, synthesis, polymeric prodrug, benzocaine