Journal2016دسترسی آزاد
Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives
Applied Sciences Vol. 6, No. 1, 27–27
چکیده
Compounds with pyrazolemoieties as nitrogen-containing heterocyclic systems have received attention owing to their diverse biological activities. Alum (KAl(SO4)2∙12H2O) is an inexpensive, reusable and nontoxic catalyst used to synthesize 1H-pyrazole derivatives via the reaction of 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one and carbonyl compound under solvent-free conditions at 60 °C. The proposed method has been used for the preparation of 1H-pyrazole derivatives to yield green products for cleaning-in-place and to avoid toxic catalysts and hazardous solvents in accordance with the philosophy of sustainable chemistry.
موضوعات و کلیدواژهها
Multicomponent Synthesis of HeterocyclesSynthesis and biological activityChemical Synthesis and ReactionsAlumCatalysisPyrazoleChemistryYield (engineering)Organic chemistryHazardous wasteGreen chemistrySolventCombinatorial chemistryWaste managementReaction mechanismMaterials science
ارجاع علمی
Mohammad Ali Zolfigol, Ardeshir Khazaei, Fatemeh Karimitabar, Masoud Hamidi. “Alum as a Catalyst for the Synthesis of Bispyrazole Derivatives.” Applied Sciences, 2016. https://doi.org/10.3390/app6010027