Journal2003دسترسی آزاد
Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones over Silica Sulfuric Acid as a Reusable Catalyst under Solvent-free Conditions
Heterocycles Vol. 60, No. 11, 2435–2435
چکیده
3,4-Dihydropyrimidin-2(1H)-ones and their sulfur analogues are efficiently synthesized by the three-component condensation of β-dicarbonyl compounds, aromatic and aliphatic aldehydes, and urea or thiourea in the presence of catalytic amounts of silica sulfuric acid under solvent-free conditions in high yields.The catalyst is recyclable and can be used several times without any decrease in the products yields.The Biginelli reaction was first reported more than a century ago and recently has been reviewed. 1,2hydropyrimidinones (DHPMs), the products of Biginelli reaction, and their derivatives have attracted
موضوعات و کلیدواژهها
Multicomponent Synthesis of HeterocyclesSynthesis and biological activityMicrowave-Assisted Synthesis and ApplicationsChemistryCatalysisSulfuric acidOrganic chemistrySolventSolid acid
ارجاع علمی
Peyman Salehi, Minoo Dabiri, Mohammad Ali Zolfigol, Mohammad Ali Bodaghi Fard. “Efficient Synthesis of 3,4-Dihydropyrimidin-2(1H)-ones over Silica Sulfuric Acid as a Reusable Catalyst under Solvent-free Conditions.” Heterocycles, 2003. https://doi.org/10.3987/com-03-9837