Journal2012دسترسی آزاد
Ionic Liquid 3-Methyl-1-sulphonic Acid Imidazolium Chloride {[Msim]Cl}: A Highly Efficient, Mild and Green Catalyst for the Synthesis of β -Acetamido Ketones
South African Journal of Chemistry Vol. 65, No. 1, 63–68
چکیده
Bronstedacidic ionic liquid 3-methyl-1-sulphonic acid imidazolium chloride {(Msim)Cl} is utilized as a highly efficient, inexpen- sive, mild and green catalyst for the synthesis of -acetamido ketones by the one-pot multi-component coupling between acetophenones, arylaldehydes, acetonitrile and acetyl chloride at room temperature. Under these conditions, the title compounds are produced in high to excellent yields and in relatively short reaction times. In addition, this method is superior to reported methods, for the synthesis of -acetamido ketones and is applicable for the synthesis of tris(-acetamido ketone).
موضوعات و کلیدواژهها
Multicomponent Synthesis of HeterocyclesChemical Synthesis and ReactionsSynthesis and biological activityChemistryIonic liquidCatalysisChlorideKetoneAcetonitrileOrganic chemistryAcetyl chlorideMedicinal chemistry
ارجاع علمی
Abdolkarim Zare, Tahereh Hekmat-Zadeh, Setareh Mirzaei-Monfared, Maria Merajoddin, Hossein Torabi-Monfared, Mohammad Ali Zolfigol, Ahmad Reza Moosavi‐Zare, Esmael Rostami, Mohammad Mokhlesi, Fatemeh Derakhshan‐Panah, Saeedeh Porbahi, Samira Balandeh. “Ionic Liquid 3-Methyl-1-sulphonic Acid Imidazolium Chloride {[Msim]Cl}: A Highly Efficient, Mild and Green Catalyst for the Synthesis of β -Acetamido Ketones.” South African Journal of Chemistry, 2012.