Journal2014
One pot synthesis of 1,2,4,5-tetrasubstituted-imidazoles catalyzed by trityl chloride in neutral media
RSC Advances Vol. 4, No. 105, 60636–60639
چکیده
Trityl chloride (TrCl or Ph3CCl) efficiently catalyzes the one-pot multi-component condensation of benzil with aldehydes, primary amines and ammonium acetate under neutral and solvent-free conditions to give 1,2,4,5-tetrasubstituted imidazoles in high to excellent yields and in short reaction times. Mechanistically, it is attractive that trityl chloride promotes the reaction by in situ generation of trityl carbocation (Ph3C+).
موضوعات و کلیدواژهها
Multicomponent Synthesis of HeterocyclesSynthesis and Reactions of Organic CompoundsSynthesis and Characterization of Heterocyclic Compoundstrityl chloride1245-tetrasubstituted imidazolesone-pot synthesismulticomponent condensationbenzilaldehydesprimary aminesammonium acetatemedia neutralitysolvent-free conditions
ارجاع علمی
Ahmad Reza Moosavi‐Zare, Zhila Asgari, Abdolkarim Zare, Mohammad Ali Zolfigol, Mohsen Shekouhy. “One pot synthesis of 1,2,4,5-tetrasubstituted-imidazoles catalyzed by trityl chloride in neutral media.” RSC Advances, 2014. https://doi.org/10.1039/c4ra10589c