Journal2013دسترسی آزاد
Synthesis of 7-Substituted Fluoroquinolone Derivatives Contain- ing Triazolidine Dione Moiety and In Vitro Evaluation of Their Cytotoxic Effects
Journal of Reports in Pharmaceutical Sciences Vol. 2, No. 1, 75–82
چکیده
A series of fluoroquinolone derivatives holding triazolidindione moieties have been synthesized and proved to be cytotoxic agents in vitro particularly against cancer cell lines (SKNMC, MCF7, A2780-CP, SW48, A549, KB, HT-29, HepG 2 ). The cytotoxic activity was assessed using MTT colorimetric assay. Our compounds had less cytotoxicity than doxorubicin in all studied cell lines.
موضوعات و کلیدواژهها
Cancer therapeutics and mechanismsSynthesis and Biological EvaluationSynthesis and biological activityCytotoxicityCytotoxic T cellIn vitroMoietyChemistryMTT assayDoxorubicinCell cultureStereochemistryCombinatorial chemistryPharmacologyBiochemistryBiologyChemotherapy
ارجاع علمی
Hadi Adibi, Leila Hosseizadeh, Maryam Mahdian, Alireza Foroumadi, Mohammad Ali Zolfigol, Shadpour E Mallakpour. “Synthesis of 7-Substituted Fluoroquinolone Derivatives Contain- ing Triazolidine Dione Moiety and In Vitro Evaluation of Their Cytotoxic Effects.” Journal of Reports in Pharmaceutical Sciences, 2013. https://doi.org/10.22110/jrps.v2i1.1078