Journal2013
Synthesis of pyranopyrazoles using isonicotinic acid as a dual and biological organocatalyst
RSC Advances Vol. 3, No. 48, 25681–25681
چکیده
In this study, a green, simple and efficient method for the preparation of 6-amino-4-(4-methoxyphenyl)-5-cyano-3-methyl-1-phenyl-1,4-dihydropyrano[2,3-c]pyrazoles by means of a one-pot four component condensation reaction of aryl aldehydes, ethyl acetoacetate, malononitrile and hydrazine hydrate is reported. The reaction utilizes isonicotinic acid as a dual and biological organocatalyst at 85 °C under solvent-free conditions.
موضوعات و کلیدواژهها
Multicomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis of Organic CompoundsMalononitrileEthyl acetoacetateChemistryHydrazine (antidepressant)Isonicotinic acidHydrateOrganic chemistryArylHydrazideCatalysisChromatography
ارجاع علمی
Mohammad Ali Zolfigol, Mahsa Tavasoli, Ahmad Reza Moosavi‐Zare, Parvin Moosavi, Hendrik G. Kruger, Morteza Shiri, Vahid Khakyzadeh. “Synthesis of pyranopyrazoles using isonicotinic acid as a dual and biological organocatalyst.” RSC Advances, 2013. https://doi.org/10.1039/c3ra45289a