Journal2016
Trityl chloride promoted the synthesis of 3-(2,6-diarylpyridin-4-yl)-1H-indoles and 2,4,6-triarylpyridines by in situ generation of trityl carbocation and anomeric based oxidation in neutral media
Canadian Journal of Chemistry Vol. 94, No. 7, 626–630
چکیده
An efficient protocol for the synthesis of 2,4,6-triarylpyridines and 3-(2,6-diarylpyridin-4-yl)-1H-indoles by the one-pot pseudo four component condensation reaction of aldehydes with acetophenones and ammonium acetate in the presence of Ph3CCl under neutral and solvent-free conditions has been reported. Mechanistically, it is interesting that trityl chloride by in situ generation of trityl carbocation (Ph3C+) promotes the reaction. In this work, seven products have been reported for the first time.
موضوعات و کلیدواژهها
Multicomponent Synthesis of HeterocyclesSynthesis of Indole DerivativesSynthesis and Reactivity of Heterocyclestrityl chloride246-triarylpyridinesindole synthesisaldehydesacetophenoneammonium acetatesolvent-free synthesismedia neutralityone-pot synthesis
ارجاع علمی
Ahmad Reza Moosavi‐Zare, Mohammad Ali Zolfigol, Zahir Rezanejad. “Trityl chloride promoted the synthesis of 3-(2,6-diarylpyridin-4-yl)-1H-indoles and 2,4,6-triarylpyridines by in situ generation of trityl carbocation and anomeric based oxidation in neutral media.” Canadian Journal of Chemistry, 2016. https://doi.org/10.1139/cjc-2015-0629